Associate Professor of Genome Sciences
John Stamatoyannopoulos, M.D., is Associate Professor of Genome Sciences and Medicine (Oncology) at the University of Washington School of Medicine. He holds degrees in Biological Sciences, Symbolic Systems, and Classics from Stanford University, and an M.D. from the University of Washington. He completed residency in Internal Medicine at Brigham and Women's Hospital, Harvard Medical School, and was a fellow in Oncology and Hematology at Dana Farber Cancer Institute and the Massachusetts General Hospital.
Dr. Stamatoyannopoulos' laboratory focuses on decoding the regulatory circuitry of the human genome through the application of high-throughput molecular and computational technologies. Major ongoing efforts are (i) to delineate the cis-regulatory architecture of the human and mouse genomes; (ii) to map and analyze transcription factor regulatory networks; (iii) to determine the functional consequences of disease-associated non-coding variation in regulatory DNA; and (iv) to develop novel technologies for visualizing and interrogating the regulatory genome. He directs the UW ENCODE Center, the Northwest Epigenome Center, and the High-Throughput Genomics Center at UW, which provides large-scale sequencing and epigenetic analysis capabilities to diverse investigators.
Principles of Gene Regulation
Course Number: GENOME 551
Course covers fundamentals of gene regulation in eukaryotes including principles of cis and trans regulation of gene expression; DNA and RNA binding proteins; role of chromatin structure in gene expression; epigenetic regulatory mechanisms; RNA-based regulatory mechanisms; and post-transcriptional regulation. The course centers on reading and discussion of landmark primary literature in the aforementioned areas.
Genomics and Proteomics
Course Number: GENOME 372
This class provides an introduction to the modern scientific disciplines of Genomics and Proteomics. Emphasis will be placed on understanding molecular and computational technologies used to sequence, map, and analyze the genomes and proteomes of living organisms from humans to bacteria. Lectures combine the description of technologies with their application to major biological questions. Lab activities provide the opportunity for students to perform analyses of 'real world' data using basic bioinformatics tools. A major objective is to familiarize students with the concepts and methods necessary to read and comprehend major scientific publications defining the fields of genomics and proteomics.