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Altius Institute for Biomedical Sciences

Depts. of Genome Science and Medicine

University of Washington

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Featured Publications:

Nat Methods October 2015Oct 2015

Functional footprinting of regulatory DNA

Nat Methods March 2016Mar 2016

Genomic footprinting

Nat Genet December 2015Dec 2015

Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo

Nature February 19, 2015Feb 2015

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

Nature November 20, 2014Nov 2014

A comparative encyclopedia of DNA elements in the mouse genome

Nature November 20, 2014Nov 2014

Conservation of trans-acting circuitry during mammalian regulatory evolution

Science November 21, 2014Nov 2014

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Science December 13, 2013Dec 2013

Exonic Transcription Factor Binding Directs Codon Choice and Affects Protein Evolution

Nat Methods January 2014Jan 2014

Coupling transcription factor occupancy to nucleosome architecture with DNase-FLASH

Nat Biotechnol January 2014Jan 2014

Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

Cell August 15, 2013Aug 2013

Developmental fate and cellular maturity encoded in human regulatory DNA landscapes

Nat Genet August 2013Aug 2013

DNase I-hypersensitive exons colocalize with promoters and distal regulatory elements

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  • ENCODE Project
  • Roadmap Epigenomics Project
  • Stem Cell Gene Therapy Program
  • Mouse ENCODE
  • Arabidopsis 2010 Project
  • Drosophila & ModENCODE